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While direct evidence connecting ammonia-induced cell death with pyroptosis is currently lacking, several studies suggest that ammonia accumulation exacerbates oxidative stress, potentially activating inflammasomes and thereby promoting pyroptotic cell death (119, 120)
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OS-related injuries can be acute (infections, systemic inflammatory response syndrome, and ischemia-reperfusion injury) or chronic (idiopathic pulmonary fibrosis, atherosclerosis, diabetes mellitus, and neurodegenerative diseases) [1,5,9,11,12,13,14]
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